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该分化系统可将 iPSC 或 ESC 高效分化为多谱系大肠类器官
分化的结肠呈复杂 3D 结构，含多种原代结肠所具备的细胞类型，包括含大肠上皮细胞、杯状细胞、神经内分泌细胞、嗜铬细胞、TA细胞、及肠隐窝干细胞
所有试剂均成分明确、不含血清
该分化系统具有优秀的稳定性，已经过 5 种 iPSC 和 1 种 ESC 测试
本产品 “ 人多能干细胞向大肠类器官定向分化系统 ” 是通过多种诱导分化方案的整合与优化而开发得到。经过 3 种人胚胎干细胞与 8 种人诱导多能干细胞的测试，确保科研人员可通过简易地操作实现人多能干细胞向结肠类器官高效、稳定的诱导分化。由本系统产生的微器官具有复杂的 3D 结构；其中包含了多种原代结肠所具备的细胞类型，包括大肠上皮细胞、神经内分泌细胞、杯状细胞、纤毛细胞、肠隐窝干细胞、肌成纤维细胞等。这些特点使得该模型适宜作为新一代的人源化精准体外模型，供研究人员从容不迫地探究发育机制、解析病理机制、发现药物靶点、筛选药毒药效等。
| 组分 | ||
• iColon Definitive Endoderm Differentiation Kit | • iColon Colonic Progenitor Differentiation Kit | • iColon Colon Growth and Maintenance Kit |
| DE Media I (10mL) | CB Media I (60mL) | MCO Media (100mL) |
| DE Media Il (10mL) | CB Media III (10mL) | |
| DE Media Ill (10mL) | ||
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