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由 “人多能干细胞向结肠类器官分化系统 (Ca. 3d0135) ” 产生
细胞：含大肠上皮细胞、杯状细胞、神经内分泌细胞、嗜铬细胞、TA细胞、肠隐窝干细胞等细胞类型
结构：呈复杂3D结构，含极化柱状上皮、空腔、肠隐窝
“ 即用型 iPSC 大肠类器官 ” 是使用人多能干细胞向大肠类器官分化系统（Ca. 3d0135）诱导分化而成。 “ 即用型 iPSC 大肠类器官 ” 具有复杂的 3D 结构；其中包含了多种原代结肠所具备的细胞类型，包括大肠上皮细胞、神经内分泌细胞、杯状细胞、纤毛细胞、肠隐窝干细胞、肌成纤维细胞等。作为新一代的人源化精准体外模型， “ 即用型 iPSC 大肠类器官 ” 可以使研究人员从容不迫地探究发育机制、解析病理机制、发现药物靶点、筛选药毒药效等。
| 遗传信息 | |||
| • 类器官类型： | • 来源： | • 性别： | |
| 大肠类器官 | 成纤维细胞 | 男 | |
| • 捐助者状态： | • 年龄： | ||
| 健康 | 32 |
Characteristics
Immunofluorescent staining showed day-40 iColons were majorly comprised of SATB2+CDX2+ colonic epithelia, in which contain goblet cell (MUC2+), neuroendocrine cells (CHGA+), enterochromaffin cells (5-HT+), TA cells (EPHB2+), and crypt stem cells (LGR5+). Scale bar = 100 μm.
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